Automated Brain Tumor Analysis from MRI Using Deep Learning
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Abstract
Accurate brain tumor classification from MRI remains essential for computer-assisted diagnosis, yet manual interpretation is time-consuming and variable. This study presents an EfficientNet-B0-based convolutional neural network for multi-class classification of glioma, meningioma, pituitary tumors, and no-tumor cases. The model was trained and evaluated on a public MRI dataset of 7023 images using a strict patient-level split to ensure unbiased assessment. A fixed EfficientNet-B0 backbone with a lightweight classification head reduces overfitting while maintaining stable learning. Performance was assessed via accuracy, precision, recall, F1-score, and specificity. The model achieved class-wise (one-vs-rest) accuracies of 96.5% for glioma, 99.1% for no tumor, 95.6% for meningioma, and 97.9% for pituitary tumors, with high specificity across all classes. A controlled comparison against ResNet50 and MobileNetV2 under identical conditions shows that EfficientNet-B0 offers a balanced trade-off between predictive performance and computational cost, achieving competitive accuracy with significantly fewer parameters and faster inference than deeper architectures. This study provides a reproducible evaluation framework, patient-level validation protocol, and systematic backbone comparison to support efficient and reliable deep learning models for multi-class brain tumor classification.
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References
- Chakrabarty, S., Sotiras, A., Milchenko, M., LaMontagne, P., Hileman, M., & Marcus, D. (2021). MRI-based identification and classification of major intracranial tumor types by using a 3D convolutional neural network: A retrospective multi-institutional analysis. Radiology: Artificial Intelligence, 3(5), e200301.
[CrossRef] [Google Scholar] - Asif, R. N., Naseem, M. T., Ahmad, M., Mazhar, T., Khan, M. A., Khan, M. A., ... & Hamam, H. (2025). Brain tumor detection empowered with ensemble deep learning approaches from MRI scan images. Scientific reports, 15(1), 15002.
[CrossRef] [Google Scholar] - Kaifi, R. (2023). A review of recent advances in brain tumor diagnosis based on AI-based classification. Diagnostics, 13(18), 3007.
[CrossRef] [Google Scholar] - Zacharaki, E. I., Wang, S., Chawla, S., Soo Yoo, D., Wolf, R., Melhem, E. R., & Davatzikos, C. (2009). Classification of brain tumor type and grade using MRI texture and shape in a machine learning scheme. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 62(6), 1609-1618.
[CrossRef] [Google Scholar] - Missaoui, R., Hechkel, W., Saadaoui, W., Helali, A., & Leo, M. (2025). Advanced deep learning and machine learning techniques for MRI brain tumor analysis: a review. Sensors, 25(9), 2746.
[CrossRef] [Google Scholar] - Rabbi, F., Dabbagh, S. R., Angin, P., Yetisen, A. K., & Tasoglu, S. (2022). Deep learning-enabled technologies for bioimage analysis. Micromachines, 13(2), 260.
[CrossRef] [Google Scholar] - Sarvamangala, D. R., & Kulkarni, R. V. (2022). Convolutional neural networks in medical image understanding: a survey. Evolutionary intelligence, 15(1), 1-22.
[CrossRef] [Google Scholar] - Khan, M. A., Sharif, M., Akram, T., Raza, M., Saba, T., & Rehman, A. (2019). Brain tumor detection and classification: A framework of marker-based watershed algorithm and multilevel priority features selection. Microscopy Research and Technique, 82(6), 909–922.
[CrossRef] [Google Scholar] - Xu, Y., Khan, T. M., Song, Y., & Meijering, E. (2025). Edge deep learning in computer vision and medical diagnostics: a comprehensive survey. Artificial Intelligence Review, 58(3), 93.
[CrossRef] [Google Scholar] - Rehman, A., Naz, S., Razzak, M. I., Akram, F., & Imran, M. (2020). A deep learning-based framework for automatic brain tumors classification using transfer learning. Circuits, Systems, and Signal Processing, 39(2), 757–775.
[CrossRef] [Google Scholar] - Osborn, A. G., Hedlund, G. L., & Salzman, K. L. (2017). Osborn‘s Brain: Imaging, Pathology, and Anatomy (2nd ed.). Elsevier.
[Google Scholar] - Krishnan, R., Gokul, P. G., Sujith, G., Anjali, T., & Abhishek, S. (2024, March). Enhancing brain tumor diagnosis: A cnn-based multi-class classification approach. In 2024 IEEE International Conference on Interdisciplinary Approaches in Technology and Management for Social Innovation (IATMSI) (Vol. 2, pp. 1-6). IEEE.
[CrossRef] [Google Scholar] - Tan, M., & Le, Q. (2019, May). Efficientnet: Rethinking model scaling for convolutional neural networks. In International conference on machine learning (pp. 6105-6114). PMLR.
[Google Scholar] - Sharma, A. K., Nandal, A., Dhaka, A., Khandelwal, R., & Varshney, S. (2023). Brain tumor classification using the modified ResNet50 model based on transfer learning. Biomedical Signal Processing and Control, 86, 105299.
[CrossRef] [Google Scholar] - Keras Team. (2023). EfficientNet — Keras Applications. Keras Documentation. Retrieved January 23, 2026, from https://keras.io/api/applications/efficientnet/
[Google Scholar] - Hashemzehi, R., Mahdavi, S. J. S., Kheirabadi, M., & Kamel, S. R. (2020). Detection of brain tumors from MRI images base on deep learning using hybrid model CNN and NADE. biocybernetics and biomedical engineering, 40(3), 1225-1232.
[CrossRef] [Google Scholar] - Díaz-Pernas, F. J., Martínez-Zarzuela, M., Antón-Rodríguez, M., & González-Ortega, D. (2021, February). A deep learning approach for brain tumor classification and segmentation using a multiscale convolutional neural network. In Healthcare (Vol. 9, No. 2, p. 153). MDPI.
[CrossRef] [Google Scholar] - Abd El Kader, I., Xu, G., Shuai, Z., Saminu, S., Javaid, I., & Salim Ahmad, I. (2021). Differential deep convolutional neural network model for brain tumor classification. Brain Sciences, 11(3), 352.
[CrossRef] [Google Scholar] - Saeedi, S., Rezayi, S., Keshavarz, H., & Niakan Kalhori, S. R. (2023). MRI-based brain tumor detection using convolutional deep learning methods and chosen machine learning techniques. BMC Medical Informatics and Decision Making, 23(1), 16.
[CrossRef] [Google Scholar] - Islam, M. M., Barua, P., Rahman, M., Ahammed, T., Akter, L., & Uddin, J. (2023). Transfer learning architectures with fine-tuning for brain tumor classification using magnetic resonance imaging. Healthcare Analytics, 4, 100270.
[CrossRef] [Google Scholar] - Albalawi, E., Almutairi, A., Alqahtani, A., Alshammari, M., & Alharbi, A. (2024). Enhancing brain tumor classification in MRI scans with a multi-layer customized convolutional neural network approach. Frontiers in Computational Neuroscience, 18, 1418546.
[CrossRef] [Google Scholar] - Iqbal, A., Jaffar, M. A., & Jahangir, R. (2024). Enhancing brain tumour multi-classification using Efficient-Net B0-based intelligent diagnosis for Internet of Medical Things (IoMT) applications. Information, 15(8), 489.
[CrossRef] [Google Scholar] - Talukder, M. A., Islam, M. M., Uddin, M. A., Layek, M. A., Acharjee, U. K., Bhuiyan, T., & Moni, M. A. (2025). A deep ensemble learning framework for brain tumor classification using data balancing and fine-tuning. Scientific Reports, 15(1), 35251.
[CrossRef] [Google Scholar] - Wong, Y., Su, E. L. M., Yeong, C. F., Holderbaum, W., & Yang, C. (2025). Brain tumor classification using MRI images and deep learning techniques. PLoS ONE, 20(5), e0322624.
[CrossRef] [Google Scholar] - Liu, K. Y., Lu, N. H., Huang, Y. H., Matsushima, A., Kimura, K., Okamoto, T., & Chen, T. B. (2025). Majority Voting Ensemble of Deep CNNs for Robust MRI-Based Brain Tumor Classification. Diagnostics, 15(14), 1782.
[CrossRef] [Google Scholar] - Sultan, H. H., Salem, N. M., & Al-Atabany, W. (2019). Multi-classification of brain tumor images using deep neural network. IEEE Access, 7, 69215–69225.
[CrossRef] [Google Scholar] - Sajja, V. R., & Al, E. (2021). Classification of brain tumors using fuzzy C-means and VGG16. Turkish Journal of Computer and Mathematics Education, 12(9), 2103–2113.
[Google Scholar] - Shorten, C., & Khoshgoftaar, T. M. (2019). A survey on image data augmentation for deep learning. Journal of big data, 6(1), 1-48.
[CrossRef] [Google Scholar] - Wang, X. (2015). Machine learning basics [PowerPoint slides]. Available at: http://whdeng.cn/Teaching/PPT_01_Machine%20learning%20Basics.pdf
[Google Scholar] - Prechelt, L. (2002). Early stopping-but when?. In Neural Networks: Tricks of the trade (pp. 55-69). Berlin, Heidelberg: Springer Berlin Heidelberg.
[CrossRef] [Google Scholar]
Cite This Article
TY - JOUR AU - Ali, Aamir AU - Raza, Aamir AU - Nazir, Iqra AU - Mohan, Swetank AU - Syed, Khaleelullah AU - Fatima, Nikhat AU - Ali, Misbah PY - 2026 DA - 2026/03/27 TI - Automated Brain Tumor Analysis from MRI Using Deep Learning JO - Biomedical Informatics and Smart Healthcare T2 - Biomedical Informatics and Smart Healthcare JF - Biomedical Informatics and Smart Healthcare VL - 2 IS - 1 SP - 62 EP - 78 DO - 10.62762/BISH.2026.687557 UR - https://www.icck.org/article/abs/BISH.2026.687557 KW - brain tumor classification KW - magnetic resonance imaging (MRI) KW - convolutional neural networks KW - efficientNet-B0 KW - deep learning KW - computer-aided diagnosis KW - medical image analysis AB - Accurate brain tumor classification from MRI remains essential for computer-assisted diagnosis, yet manual interpretation is time-consuming and variable. This study presents an EfficientNet-B0-based convolutional neural network for multi-class classification of glioma, meningioma, pituitary tumors, and no-tumor cases. The model was trained and evaluated on a public MRI dataset of 7023 images using a strict patient-level split to ensure unbiased assessment. A fixed EfficientNet-B0 backbone with a lightweight classification head reduces overfitting while maintaining stable learning. Performance was assessed via accuracy, precision, recall, F1-score, and specificity. The model achieved class-wise (one-vs-rest) accuracies of 96.5% for glioma, 99.1% for no tumor, 95.6% for meningioma, and 97.9% for pituitary tumors, with high specificity across all classes. A controlled comparison against ResNet50 and MobileNetV2 under identical conditions shows that EfficientNet-B0 offers a balanced trade-off between predictive performance and computational cost, achieving competitive accuracy with significantly fewer parameters and faster inference than deeper architectures. This study provides a reproducible evaluation framework, patient-level validation protocol, and systematic backbone comparison to support efficient and reliable deep learning models for multi-class brain tumor classification. SN - 3068-5524 PB - Institute of Central Computation and Knowledge LA - English ER -
@article{Ali2026Automated,
author = {Aamir Ali and Aamir Raza and Iqra Nazir and Swetank Mohan and Khaleelullah Syed and Nikhat Fatima and Misbah Ali},
title = {Automated Brain Tumor Analysis from MRI Using Deep Learning},
journal = {Biomedical Informatics and Smart Healthcare},
year = {2026},
volume = {2},
number = {1},
pages = {62-78},
doi = {10.62762/BISH.2026.687557},
url = {https://www.icck.org/article/abs/BISH.2026.687557},
abstract = {Accurate brain tumor classification from MRI remains essential for computer-assisted diagnosis, yet manual interpretation is time-consuming and variable. This study presents an EfficientNet-B0-based convolutional neural network for multi-class classification of glioma, meningioma, pituitary tumors, and no-tumor cases. The model was trained and evaluated on a public MRI dataset of 7023 images using a strict patient-level split to ensure unbiased assessment. A fixed EfficientNet-B0 backbone with a lightweight classification head reduces overfitting while maintaining stable learning. Performance was assessed via accuracy, precision, recall, F1-score, and specificity. The model achieved class-wise (one-vs-rest) accuracies of 96.5\% for glioma, 99.1\% for no tumor, 95.6\% for meningioma, and 97.9\% for pituitary tumors, with high specificity across all classes. A controlled comparison against ResNet50 and MobileNetV2 under identical conditions shows that EfficientNet-B0 offers a balanced trade-off between predictive performance and computational cost, achieving competitive accuracy with significantly fewer parameters and faster inference than deeper architectures. This study provides a reproducible evaluation framework, patient-level validation protocol, and systematic backbone comparison to support efficient and reliable deep learning models for multi-class brain tumor classification.},
keywords = {brain tumor classification, magnetic resonance imaging (MRI), convolutional neural networks, efficientNet-B0, deep learning, computer-aided diagnosis, medical image analysis},
issn = {3068-5524},
publisher = {Institute of Central Computation and Knowledge}
}
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Copyright © 2026 by the Author(s). Published by Institute of Central Computation and Knowledge. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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