Dengue is a major public health concern in tropical and subtropical regions worldwide. The World Health Organization (WHO) classifies dengue as an endemic disease in more than 125 countries, with approximately 75% of the affected population residing in the Asia-Pacific region, including the Philippines. This study aimed to compare and analyze the four-dengue virus (DENV) serotypes in terms of gene and protein sequence alignment, structural modeling, and identification of candidate epitopes within envelope protein domain III (E-DIII). The DENV E-DIII region plays a critical role in host-cell interaction and is considered a promising immunogenic target for the development of dengue subunit vac... More >

Chronic Kidney Disease (CKD) affects 697.5 million people globally, with \~{}115 million in India. Early detection is clinically challenging as the disease remains asymptomatic through stages 1–3, particularly in resource-limited rural settings like Madhya Pradesh. While high-accuracy black-box models (SVM, Random Forest, DNN) achieve 91.5–98% accuracy on the UCI CKD benchmark, they lack interpretability—creating a Transparency Gap that hinders clinical adoption. This paper proposes ANFIS-PSO, a Particle Swarm Optimization-tuned Adaptive Neuro-Fuzzy Inference System for early CKD diagnosis. A five-stage pipeline incorporating KNN imputation and Min-Max normalization was applied to the... More >

Mental health disorders pose a significant global burden, yet integrated non-invasive tools for simultaneous neurodiagnosis and therapy remain limited. This paper introduces IRENIC, a wearable prototype integrating an EEG skull cap for real-time brain monitoring, pre-stored SPECT/PET databases, AR visualization, psychometric tools, AI algorithms — including CNNs and reinforcement learning — that correlate EEG with neuroimaging data including brain stimulation games, cognitive therapy, calming music, and yoga mudras. The validated conceptual design enables EEG acquisition, AI-powered multi-modal correlation, psychometric evaluation, and closed-loop therapy delivery within a single platfor... More >