This inaugural editorial aims to provide a comprehensive and in-depth exposition of the profound historical context, core academic value, and long-term vision underlying the establishment of ICCK Transactions on Intelligent Cyber-Physical Systems (hereinafter referred to as “the Journal”). We are standing at the forefront of the Fourth Industrial Revolution, driven by the rapid advancement of cyber-physical integration technologies. As the central engine of this transformative wave, intelligent cyber-physical systems—through the deep and organic fusion of computing, communication, control technologies, and artificial intelligence-are fundamentally reshaping industrial infrastructures,... More >