DNA data storage is a promising technology that utilizes computer simulation and offers high-density and durable digital information storage. It is challenging to store massive image data in a small amount of DNA without losing the original data since nonspecific hybridization errors occur frequently and severely affect the durability of stored data. This work proposes a novel approach (RFS-codec) comprising an image fraction strategy and an innovative codec method to split and encode image data into DNA storage, respectively. The fraction strategy contributes by delivering a cost-effective solution for image storage in DNA. The codec method offers an encryption mechanism to convert binary d... More >

As a carrier of genetic information, the precise design and optimization of nucleic acid (DNA or RNA) sequences are of critical importance for the realization of specific biological functions. From synthesizing genes to designing novel nucleic acid drugs, from constructing efficient expression vectors to modifying microbial metabolic pathways, all are inseparable from the fine regulation of nucleic acid sequences. The primary purpose of nucleic acid sequence design is to generate new sequences tailored to specific requirements for gene expression, function prediction, drug development, and other applications. In this paper, we first review the theoretical basis of nucleic acid sequence desig... More >

Presents the inaugural editorial for this issue of the publication. More >