Uncovering COVID-19 Death Risk for Life on the Line with Machine Learning Precision
Research Article  ·  Published: 30 March 2025
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ICCK Transactions on Neural Computing
Volume 1, Issue 1, 2025: 30-43
Research Article Open Access

Uncovering COVID-19 Death Risk for Life on the Line with Machine Learning Precision

1 Department of Information Engineering, Computer Science and Mathematics, University of L’Aquila, 67100 L'Aquila, Italy
2 Department of Computer Science, The TIMES Institute, Multan 60000, Pakistan
3 Al-Khawarizmi Institute of Computer Science (KICS), University of Engineering & Technology (UET), Lahore, Pakistan
4 International Islamic University, Islamabad 44000, Pakistan
* Corresponding Author: Muhammad Adnan Hasnain, [email protected]
Volume 1, Issue 1
You have full access to this open access article · CC BY 4.0 License

Article Information

Abstract

The global healthcare systems have faced unprecedented challenges due to the COVID-19 pandemic, necessitating innovative neural computing solutions to inform critical decision-making. In this study, we introduce a neural-inspired machine learning framework to predict COVID-19 mortality risk, utilizing a dataset comprising over one million records. We developed and evaluated a suite of advanced models—Decision Tree, Random Forest, Logistic Regression, Support Vector Machine, Gradient Boost Classifier, and a neural ensemble-based Voting Classifier—to analyze the influence of demographics, symptoms, and preexisting conditions on mortality predictions. Through meticulous feature engineering and data preprocessing, our approach yielded profound insights, with the Voting Classifier achieving an exceptional 93% accuracy on test data, outperforming Random Forest and Logistic Regression (both at 91%). Key risk factors identified include age and preexisting conditions, complemented by nuanced patterns linked to symptoms and socioeconomic-demographic factors. Model robustness was rigorously validated using F1-score and ROC curves, affirming its reliability and generalization capacity. The Voting Classifier’s neural ensemble design, integrating diverse model outputs, exemplifies the power of neural computing principles in processing complex health data. This framework not only enhances predictive accuracy but also provides actionable insights for public health, enabling optimized resource allocation, prioritized care for high-risk patients, and improved survival outcomes. Beyond elucidating COVID-19 mortality dynamics, this research underscores the transformative potential of neural computing in tackling global health crises, establishing a robust foundation for data-driven strategies in future challenges.

Graphical Abstract

Uncovering COVID-19 Death Risk for Life on the Line with Machine Learning Precision

Keywords

COVID-19 health care analytics predictive modeling mortality risk

Data Availability Statement

Data will be made available on request.

Funding

This work was supported without any funding.

Conflicts of Interest

The authors declare no conflicts of interest. 

Ethical Approval and Consent to Participate

This work uses publicly available, anonymized Mexico General Directorate of Epidemiology COVID-19 Open Data from the General Directorate of Epidemiology under the Ministry of Health of Mexico. All data were fully de-identified prior to use. Therefore, ethical approval and informed consent were not required, in accordance with institutional guidelines and applicable regulations.

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Cite This Article

APA Style
Hasnain, M. A., Abbas, T., Janjua, J. I., & Khan, S. (2025). Uncovering COVID-19 Death Risk for Life on the Line with Machine Learning Precision. ICCK Transactions on Neural Computing, 1(1), 30–43. https://doi.org/10.62762/TNC.2025.507897
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Compatible with EndNote, Zotero, Mendeley, and other reference managers
TY  - JOUR
AU  - Hasnain, Muhammad Adnan
AU  - Abbas, Tahir
AU  - Janjua, Jamshaid Iqbal
AU  - Khan, Sunawar
PY  - 2025
DA  - 2025/03/30
TI  - Uncovering COVID-19 Death Risk for Life on the Line with Machine Learning Precision
JO  - ICCK Transactions on Neural Computing
T2  - ICCK Transactions on Neural Computing
JF  - ICCK Transactions on Neural Computing
VL  - 1
IS  - 1
SP  - 30
EP  - 43
DO  - 10.62762/TNC.2025.507897
UR  - https://www.icck.org/article/abs/TNC.2025.507897
KW  - COVID-19
KW  - health care analytics
KW  - predictive modeling mortality risk
AB  - The global healthcare systems have faced unprecedented challenges due to the COVID-19 pandemic, necessitating innovative neural computing solutions to inform critical decision-making. In this study, we introduce a neural-inspired machine learning framework to predict COVID-19 mortality risk, utilizing a dataset comprising over one million records. We developed and evaluated a suite of advanced models—Decision Tree, Random Forest, Logistic Regression, Support Vector Machine, Gradient Boost Classifier, and a neural ensemble-based Voting Classifier—to analyze the influence of demographics, symptoms, and preexisting conditions on mortality predictions. Through meticulous feature engineering and data preprocessing, our approach yielded profound insights, with the Voting Classifier achieving an exceptional 93% accuracy on test data, outperforming Random Forest and Logistic Regression (both at 91%). Key risk factors identified include age and preexisting conditions, complemented by nuanced patterns linked to symptoms and socioeconomic-demographic factors. Model robustness was rigorously validated using F1-score and ROC curves, affirming its reliability and generalization capacity. The Voting Classifier’s neural ensemble design, integrating diverse model outputs, exemplifies the power of neural computing principles in processing complex health data. This framework not only enhances predictive accuracy but also provides actionable insights for public health, enabling optimized resource allocation, prioritized care for high-risk patients, and improved survival outcomes. Beyond elucidating COVID-19 mortality dynamics, this research underscores the transformative potential of neural computing in tackling global health crises, establishing a robust foundation for data-driven strategies in future challenges.
SN  - 3068-7519
PB  - Institute of Central Computation and Knowledge
LA  - English
ER  - 
BibTeX Format
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@article{Hasnain2025Uncovering,
  author = {Muhammad Adnan Hasnain and Tahir Abbas and Jamshaid Iqbal Janjua and Sunawar Khan},
  title = {Uncovering COVID-19 Death Risk for Life on the Line with Machine Learning Precision},
  journal = {ICCK Transactions on Neural Computing},
  year = {2025},
  volume = {1},
  number = {1},
  pages = {30-43},
  doi = {10.62762/TNC.2025.507897},
  url = {https://www.icck.org/article/abs/TNC.2025.507897},
  abstract = {The global healthcare systems have faced unprecedented challenges due to the COVID-19 pandemic, necessitating innovative neural computing solutions to inform critical decision-making. In this study, we introduce a neural-inspired machine learning framework to predict COVID-19 mortality risk, utilizing a dataset comprising over one million records. We developed and evaluated a suite of advanced models—Decision Tree, Random Forest, Logistic Regression, Support Vector Machine, Gradient Boost Classifier, and a neural ensemble-based Voting Classifier—to analyze the influence of demographics, symptoms, and preexisting conditions on mortality predictions. Through meticulous feature engineering and data preprocessing, our approach yielded profound insights, with the Voting Classifier achieving an exceptional 93\% accuracy on test data, outperforming Random Forest and Logistic Regression (both at 91\%). Key risk factors identified include age and preexisting conditions, complemented by nuanced patterns linked to symptoms and socioeconomic-demographic factors. Model robustness was rigorously validated using F1-score and ROC curves, affirming its reliability and generalization capacity. The Voting Classifier’s neural ensemble design, integrating diverse model outputs, exemplifies the power of neural computing principles in processing complex health data. This framework not only enhances predictive accuracy but also provides actionable insights for public health, enabling optimized resource allocation, prioritized care for high-risk patients, and improved survival outcomes. Beyond elucidating COVID-19 mortality dynamics, this research underscores the transformative potential of neural computing in tackling global health crises, establishing a robust foundation for data-driven strategies in future challenges.},
  keywords = {COVID-19, health care analytics, predictive modeling mortality risk},
  issn = {3068-7519},
  publisher = {Institute of Central Computation and Knowledge}
}

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