ICCK

Ryan Wyton

Southampton Solent University, GB

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Free Access | Research Article | 27 September 2026
Non-Invasive Parkinson's Disease Screening from Vocal Biomarkers: A Subject-Level Machine Learning Framework with Bayesian Optimisation and Explainable AI
ICCK Transactions on Sensing, Communication, and Control | Volume 3, Issue 3: 197-209, 2026 | DOI: 10.62762/TSCC.2026.365257
Abstract
An estimated ten million people live with Parkinson's, yet timely diagnosis remains constrained by specialist assessment, costly imaging, and unequal care access. Phonation analysis offers a low-cost alternative: dopaminergic degeneration causes vocal impairments years before motor symptoms emerge, enabling community screening. However, existing ML approaches are limited by recording-level data leakage and opacity. This paper presents a four-phase acoustic framework-spanning signal acquisition, feature processing, and interpretable decision support-applied to a multi-type Parkinson's speech dataset (40 training, 28 blind-test). The framework enforces subject-level partitioning via GroupKFold... More >

Graphical Abstract
Non-Invasive Parkinson's Disease Screening from Vocal Biomarkers: A Subject-Level Machine Learning Framework with Bayesian Optimisation and Explainable AI