This work reports the performance optimization of PTB7:PCBM-based inverted organic solar cells (IOSCs) using the Organic and Hybrid Materials Nano (OghmaNano) simulator. A comprehensive study was carried out by varying the key performance parameters, such as active layer thickness (AL), charge transport layers (CTLs), operating temperature, charge carrier mobilities(CCMs), and incident light intensity. The results showed that the carrier concentrations and mobilities (e.g, electron mobility ($\mu_e$) and hole mobility ($\mu$h)) significantly changed with operating temperature (280 to 400 K), affecting the power conversion efficiency (PCE). Additionally, changing light intensity from 0.1 to 1... More >