The absence of robust and reliable $in \, vitro$ models that can accurately recapitulate the biological characteristics of many mammalian tissues and disease states represents a major barrier to both basic and translational research, owing to limited sample availability and ethical concerns. Stem cell-derived self-assembling three-dimensional (3D) organoids can replicate key structural and functional aspects of organs in a more physiologically relevant manner than traditional 2D models, thus providing a superior platform for simulating human physiology and pathology. To date, researchers have developed organoid models for a variety of endocrine tissues and their associated diseases (includ... More >