Background: Practical implementation of radiomics research faces significant data accessibility challenges due to privacy and ethical restrictions on multicenter data aggregation. Federated Learning (FL) provides a secure distributed framework that preserves data privacy through cryptographic techniques. Its adoption in radiomics is an emerging trend, enabling collaborative training without sharing sensitive imaging data. However, the inherently Non-IID data distribution across clients in FL often leads to class imbalance, which can substantially degrade global model performance. Purpose: To develop a privacy-preserving, multicenter collaborative CT-radiomics model for evaluating neoadjuvant... More >