Tumor-associated macrophages and extracellular matrix remodeling are important components shaping the microenvironment of hepatocellular carcinoma (HCC). This study examined whether forkhead box A2 (FOXA2) expression is associated with extracellular matrix (ECM)/stromal remodeling, focal adhesion kinase (FAK)--Yes-associated protein (YAP)-related transcriptional features, and immune-stromal characteristics in HCC. Using The Cancer Genome Atlas liver hepatocellular carcinoma (TCGA-LIHC) cohort for discovery and the ICGC-LIRI-JP and GSE14520 datasets for expression validation, we performed differential expression, enrichment analysis, single-sample gene set scoring, ESTIMATE-based microenviron... More >