Biomedical Informatics and Smart Healthcare | Volume 2, Issue 1: 20-37, 2026 | DOI: 10.62762/BISH.2026.470997
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, predominantly affecting older adults. Early detection is crucial, as subtle motor and non-motor symptoms frequently overlap with other conditions, often resulting in delayed diagnosis. Many existing models rely on costly and less accessible imaging modalities such as MRI or PET scans, limiting their applicability in resource-constrained settings where only routine clinical data are available. This study develops interpretable AI models for early PD detection using structured clinical variables, incorporating feature selection techniques. Feature selection was conducted via Random Forest (RF) importance... More >
Graphical Abstract