Liquid Phase Transmission Electron Microscopy for Nanomaterial Dynamics and Applications
Review Article  ·  Published: 28 May 2026
Issue cover
Journal of Advanced Materials Research
Volume 2, Issue 2, 2026: 151-168
Review Article Open Access

Liquid Phase Transmission Electron Microscopy for Nanomaterial Dynamics and Applications

1 SEU-FEI Nano-Pico Center, Key Lab of MEMS of Ministry of Education, School of Integrated Circuits, Southeast University, Nanjing 210096, China
2 Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley 94720, United States
These authors contributed equally to this work
* Corresponding Author: Qiubo Zhang, [email protected]
Volume 2, Issue 2

Article Information

Abstract

Nanomaterials play crucial roles in energy, catalysis, biomedicine, and electronic devices. A systematic and in-depth understanding of the dynamic behavior during structural evolution and practical applications is significant. Liquid phase transmission electron microscopy (LP-TEM) is a powerful in situ characterization technique. It provides atomic-scale resolution and high temporal resolution observation for the evolution of nanomaterials in solution and has become a crucial tool for studying the dynamic processes of nanomaterials. This review summarizes the latest research progress of LP-TEM in nanomaterial nucleation and growth, etching and corrosion, self-assembly, and electrochemical applications, which is significant for understanding the developmental trajectory of liquid phase electron microscopy. Furthermore, this review outlines the challenges currently faced by LP-TEM and provides perspectives on future strategies to overcome these limitations. This review aims to provide a new perspective for broader nanomaterials research and to expand the application of LP-TEM in nanomaterials research.

Graphical Abstract

Liquid Phase Transmission Electron Microscopy for Nanomaterial Dynamics and Applications

Keywords

liquid phase TEM nanomaterials nucleation and growth etching and corrosion assembly electrochemistry

Data Availability Statement

Data will be made available on request.

Funding

This work was supported by the Research Start-up Fund for New Teachers of Southeast University under Grant 4006012510.

Conflicts of Interest

Qiubo Zhang serves as a Editorial Board Member of the Journal of Advanced Materials Research. To ensure the integrity of the peer-review process, Qiubo Zhang had no involvement in the editorial handling, peer review, or decision-making process for this manuscript. The manuscript was handled independently by another editor in accordance with the journal's editorial policies. The remaining authors declare no conflicts of interest. Note: The SEU-FEI Nano-Pico Center is a joint laboratory between Southeast University and FEI Company (Thermo Fisher Scientific). The authors confirm that this affiliation did not influence the objectivity of this review.

AI Use Statement

The authors declare that ChatGPT-5 was used solely for language polishing in the preparation of this manuscript, and the authors have reviewed and take full responsibility for the content.

Ethical Approval and Consent to Participate

Not applicable.

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Cite This Article

APA Style
Shang, Z., Su, Y., Chen, Y., & Zhang, Q. (2026). Liquid Phase Transmission Electron Microscopy for Nanomaterial Dynamics and Applications. Journal of Advanced Materials Research, 2(2), 151-168. https://doi.org/10.62762/JAMR.2026.738602
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TY  - JOUR
AU  - Shang, Ziming
AU  - Su, Yu
AU  - Chen, Yi
AU  - Zhang, Qiubo
PY  - 2026
DA  - 2026/05/28
TI  - Liquid Phase Transmission Electron Microscopy for Nanomaterial Dynamics and Applications
JO  - Journal of Advanced Materials Research
T2  - Journal of Advanced Materials Research
JF  - Journal of Advanced Materials Research
VL  - 2
IS  - 2
SP  - 151
EP  - 168
DO  - 10.62762/JAMR.2026.738602
UR  - https://www.icck.org/article/abs/JAMR.2026.738602
KW  - liquid phase TEM
KW  - nanomaterials
KW  - nucleation and growth
KW  - etching and corrosion
KW  - assembly
KW  - electrochemistry
AB  - Nanomaterials play crucial roles in energy, catalysis, biomedicine, and electronic devices. A systematic and in-depth understanding of the dynamic behavior during structural evolution and practical applications is significant. Liquid phase transmission electron microscopy (LP-TEM) is a powerful in situ characterization technique. It provides atomic-scale resolution and high temporal resolution observation for the evolution of nanomaterials in solution and has become a crucial tool for studying the dynamic processes of nanomaterials. This review summarizes the latest research progress of LP-TEM in nanomaterial nucleation and growth, etching and corrosion, self-assembly, and electrochemical applications, which is significant for understanding the developmental trajectory of liquid phase electron microscopy. Furthermore, this review outlines the challenges currently faced by LP-TEM and provides perspectives on future strategies to overcome these limitations. This review aims to provide a new perspective for broader nanomaterials research and to expand the application of LP-TEM in nanomaterials research.
SN  - 3070-5851
PB  - Institute of Central Computation and Knowledge
LA  - English
ER  - 
BibTeX Format
Compatible with LaTeX, BibTeX, and other reference managers
@article{Shang2026Liquid,
  author = {Ziming Shang and Yu Su and Yi Chen and Qiubo Zhang},
  title = {Liquid Phase Transmission Electron Microscopy for Nanomaterial Dynamics and Applications},
  journal = {Journal of Advanced Materials Research},
  year = {2026},
  volume = {2},
  number = {2},
  pages = {151-168},
  doi = {10.62762/JAMR.2026.738602},
  url = {https://www.icck.org/article/abs/JAMR.2026.738602},
  abstract = {Nanomaterials play crucial roles in energy, catalysis, biomedicine, and electronic devices. A systematic and in-depth understanding of the dynamic behavior during structural evolution and practical applications is significant. Liquid phase transmission electron microscopy (LP-TEM) is a powerful in situ characterization technique. It provides atomic-scale resolution and high temporal resolution observation for the evolution of nanomaterials in solution and has become a crucial tool for studying the dynamic processes of nanomaterials. This review summarizes the latest research progress of LP-TEM in nanomaterial nucleation and growth, etching and corrosion, self-assembly, and electrochemical applications, which is significant for understanding the developmental trajectory of liquid phase electron microscopy. Furthermore, this review outlines the challenges currently faced by LP-TEM and provides perspectives on future strategies to overcome these limitations. This review aims to provide a new perspective for broader nanomaterials research and to expand the application of LP-TEM in nanomaterials research.},
  keywords = {liquid phase TEM, nanomaterials, nucleation and growth, etching and corrosion, assembly, electrochemistry},
  issn = {3070-5851},
  publisher = {Institute of Central Computation and Knowledge}
}

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