In shale reservoirs, fracturing fluid can be easily absorbed into the pore space due to the strong capillary force of shale. These invading fluids can impact the rock mechanical properties and creep behavior characteristics of shale under water-rock interaction. This paper discussed the influence of water-rock interaction on the mechanical parameters and creep behavior of shale rocks based on shale hydration swelling experiments, acoustic-triaxial compression tests, and shale creep experiments. The experiments show that: There are two stages of shale hydration swelling: rapid swelling stage and stable swelling stage. Temperature mainly impacts the hydration swelling rate, while the type of liquid mainly impacts the hydration swelling amplitude. Water-rock interaction can damage the shale mechanical properties and cause the decrease of the Young's modulus, Poisson's ratio, and compressive strength. The degradation rate of Young's modulus and compressive strength significantly decreases after 10 days of water rock interaction. Water rock interaction can also alter the creep characteristics of shale, increasing the amplitude and rate of shale creep. The lower the liquid mineralization, the stronger the shale creep. The higher the temperature, the stronger the creep of shale.