This study developed a machine learning model for early risk stratification of Down syndrome by integrating maternal serum biomarkers and ultrasound measurements. A retrospective multicentre dataset was used, including maternal age, AFP, HCG, INHIBIN-A, and ultrasound parameters (NT, CRL). After imputing missing data and engineering features (e.g., Age_NT_interaction), a Gradient Boosting Machine (GBM) was trained and evaluated using AUROC, precision, recall, and F1-score. The model achieved high performance (AUROC: 0.9921; precision: 1.00; F1-score: 0.91; accuracy: 0.97). SHAP analysis identified key interactions—particularly Age_NT, Age_HCG, and Age_PAPP-A—as major contributors. High m... More >

This study employs K-means clustering to analyze long-term cardiovascular complications in COVID-19 patients through ECG parameters, demographics, comorbidities, and hospitalization data. Three distinct clusters emerged: Cluster 0 (moderate heart rate variability/ICU admissions), Cluster 1 (lower variability/admissions), and Cluster 2 (higher variability/admissions, indicating elevated risk). Bootstrap validation confirmed model robustness, supported by high silhouette scores and consistent cluster labels. The novel integration of multimodal data with machine learning revealed hidden cardiovascular outcome patterns, demonstrating clinical utility for risk stratification. Findings underscore... More >