This paper provides a comprehensive analysis of the economic implications of implementing advanced loss-reduction measures in electrical distribution networks, as observed across developed economies. The study evaluates a set of technical and infrastructural interventions that have demonstrated significant potential in enhancing network efficiency and reducing operational losses. These measures encompass the large-scale deployment of smart electricity meters, the replacement of conventional distribution transformers with units employing amorphous metal cores, and the mitigation of transformer overloading through the installation of higher-rated capacity units. Additional strategies include increasing the cross-sectional area of distribution conductors, optimizing feeder configurations by extending medium-voltage lines, shortening low-voltage feeders, and relocating substations closer to feeder midpoints. Moreover, the paper examines the transition from the conventional “one substation–multiple feeders” configuration toward a more efficient “one substation–one feeder” supply concept. The results of the analysis confirm that the implementation of these measures is both technically and economically justified, yielding substantial improvements in network performance, energy efficiency, and long-term operational sustainability.