A Comparative Analysis of Various Transfer Learning-Based Deep Learning Frameworks Using Brain Tumor MRI
Research Article  ·  Published: 19 October 2026
Issue cover
ICCK Transactions on Machine Intelligence
Volume 2, Issue 4, 2026: 200-212
Research Article Free to Read

A Comparative Analysis of Various Transfer Learning-Based Deep Learning Frameworks Using Brain Tumor MRI

1 Department of Computer Science, Banasthali Vidyapith, Rajasthan 304022, India
* Corresponding Author: Sunil Kumar Agarwal, [email protected]
Volume 2, Issue 4
You have access to this article · Limited-Time Free Access

Article Information

Abstract

Brain tumors are a critical and challenging health issue worldwide, and they often reduce patient survival if they are not identified at an early stage. This study presents an automatic approach to identify and classify brain tumor magnetic resonance imaging (MRI) scans using several pre-trained deep learning frameworks and compares their relative performance. Four popular frameworks, namely VGG16, Xception, ResNet50, and MobileNetV1, were fine-tuned with a transfer learning technique on 2870 brain tumor MRI training images to predict four classes (glioma, meningioma, pituitary tumor, and no tumor). A quantitative comparison among all applied frameworks was performed using accuracy, precision, recall, and F1-score. On the held-out test set, VGG16 achieved the highest accuracy (70.1%), followed by Xception (63.7%), MobileNetV1 (53.3%), and ResNet50 (50.8%). The results indicate that VGG16 and Xception outperform the other two frameworks under the same transfer learning setting, while all models show low recall for the glioma class. The study provides a baseline comparison of pre-trained frameworks for brain tumor MRI classification and outlines directions for future research.

Graphical Abstract

A Comparative Analysis of Various Transfer Learning-Based Deep Learning Frameworks Using Brain Tumor MRI

Keywords

Brain tumor MRI classification transfer learning pre-trained model VGG16 Xception ResNet50 MobileNetV1

Data Availability Statement

The MRI dataset analyzed in this study is publicly available at https://www.kaggle.com/datasets/sartajbhuvaji/brain-tumor-classification-mri. The code and trained models are available from the corresponding author upon reasonable request.

Funding

This work was supported without any funding.

Conflicts of Interest

The authors declare no conflicts of interest.

AI Use Statement

The authors declare that no generative AI was used in the preparation of this manuscript.

Ethical Approval and Consent to Participate

Not applicable. This study involved secondary analysis of a publicly available, de-identified MRI dataset and did not involve the recruitment of human participants, collection of identifiable personal information, or animal experiments.

References

  1. Ostrom, Q. T., Cioffi, G., Waite, K., Kruchko, C., & Barnholtz-Sloan, J. S. (2021). CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro-oncology, 23(Supplement_3), iii1-iii105.
    [CrossRef] [Google Scholar]
  2. Lapointe, S., Perry, A., & Butowski, N. A. (2018). Primary brain tumours in adults. The Lancet, 392(10145), 432-446.
    [CrossRef] [Google Scholar]
  3. Biratu, E. S., Schwenker, F., Ayano, Y. M., & Debelee, T. G. (2021). A survey of brain tumor segmentation and classification algorithms. Journal of Imaging, 7(9), 179.
    [CrossRef] [Google Scholar]
  4. Amin, J., Sharif, M., Yasmin, M., & Fernandes, S. L. (2020). A distinctive approach in brain tumor detection and classification using MRI. Pattern Recognition Letters, 139, 118-127.
    [CrossRef] [Google Scholar]
  5. Iqbal, M. J., Javed, Z., Sadia, H., Qureshi, I. A., Irshad, A., Ahmed, R., ... & Sharifi-Rad, J. (2021). Clinical applications of artificial intelligence and machine learning in cancer diagnosis: looking into the future. Cancer Cell International, 21(1), 270.
    [CrossRef] [Google Scholar]
  6. Alzubaidi, L., Zhang, J., Humaidi, A. J., Al-Dujaili, A., Duan, Y., Al-Shamma, O., ... & Farhan, L. (2021). Review of deep learning: concepts, CNN architectures, challenges, applications, future directions. Journal of Big Data, 8(1), 53.
    [CrossRef] [Google Scholar]
  7. Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., ... & S\'anchez, C. I. (2017). A survey on deep learning in medical image analysis. Medical Image Analysis, 42, 60-88.
    [CrossRef] [Google Scholar]
  8. Hosna, A., Merry, E., Gyalmo, J., Alom, Z., Aung, Z., & Azim, M. A. (2022). Transfer learning: a friendly introduction. Journal of big data, 9(1), 102.
    [CrossRef] [Google Scholar]
  9. Xie, Y., Zaccagna, F., Rundo, L., Testa, C., Agati, R., Lodi, R., ... & Tonon, C. (2022). Convolutional neural network techniques for brain tumor classification (from 2015 to 2022): Review, challenges, and future perspectives. Diagnostics, 12(8), 1850.
    [CrossRef] [Google Scholar]
  10. Babu Vimala, B., Srinivasan, S., Mathivanan, S. K., Mahalakshmi, Jayagopal, P., & Dalu, G. T. (2023). Detection and classification of brain tumor using hybrid deep learning models. Scientific reports, 13(1), 23029.
    [CrossRef] [Google Scholar]
  11. Basheera, S., & Satya Sai Ram, M. (2019, March). Classification of brain tumors using deep features extracted using CNN. In Journal of Physics: Conference Series (Vol. 1172, No. 1, p. 012016). IOP Publishing.
    [CrossRef] [Google Scholar]
  12. Sultan, H. H., Salem, N. M., & Al-Atabany, W. (2019). Multi-classification of brain tumor images using deep neural network. IEEE Access, 7, 69215-69225.
    [CrossRef] [Google Scholar]
  13. Singh, A., Deshmukh, R., Jha, R., Shahare, N., & Verma, S. (2020). Brain tumor classification using convolutional neural network. International Journal of Advance Research and Innovative Ideas in Education, 6(2), 1353-1357. https://scispace.com/papers/brain-tumor-classification-using-convolutional-neural-efzz4asxdy
    [Google Scholar]
  14. Abiwinanda, N., Hanif, M., Hesaputra, S. T., Handayani, A., & Mengko, T. R. (2018, May). Brain tumor classification using convolutional neural network. In World Congress on Medical Physics and Biomedical Engineering 2018: June 3–8, 2018, Prague, Czech Republic (Vol. 1) (pp. 183-189). Singapore: Springer Nature Singapore.
    [CrossRef] [Google Scholar]
  15. Minarno, A. E., Cokro Mandiri, M. H., Munarko, Y., & Hariyady, H. (2021). Convolutional neural network with hyperparameter tuning for brain tumor classification. Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control, 6(2).
    [CrossRef] [Google Scholar]
  16. Mukkapati, N., & Anbarasi, M. S. (2022). Brain tumor classification based on enhanced CNN model. Revue d'Intelligence Artificielle, 36(1), 125-130.
    [CrossRef] [Google Scholar]
  17. Lo, C. M., Chen, Y. C., Weng, R. C., & Hsieh, K. L. C. (2019). Intelligent glioma grading based on deep transfer learning of MRI radiomic features. Applied Sciences, 9(22), 4926.
    [CrossRef] [Google Scholar]
  18. Rehman, A., Naz, S., Razzak, M. I., Akram, F., & Imran, M. (2020). A deep learning-based framework for automatic brain tumors classification using transfer learning. Circuits, Systems, and Signal Processing, 39(2), 757-775.
    [CrossRef] [Google Scholar]
  19. Chelghoum, R., Ikhlef, A., Hameurlaine, A., & Jacquir, S. (2020). Transfer learning using convolutional neural network architectures for brain tumor classification from MRI images. In Artificial Intelligence Applications and Innovations (AIAI 2020), IFIP Advances in Information and Communication Technology (Vol. 583, pp. 189-200). Springer, Cham.
    [CrossRef] [Google Scholar]
  20. Arbane, M., Benlamri, R., Brik, Y., & Djerioui, M. (2021). Transfer learning for automatic brain tumor classification using MRI images. In 2020 2nd International Workshop on Human-Centric Smart Environments for Health and Well-being (IHSH) (pp. 210-214). IEEE.
    [CrossRef] [Google Scholar]
  21. Prakash, R. M., Kumari, R. S. S., Valarmathi, K., & Ramalakshmi, K. (2023). Classification of brain tumours from MR images with an enhanced deep learning approach using densely connected convolutional network. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 11(2), 266-277.
    [CrossRef] [Google Scholar]
  22. Arya, M. K., & Agrawal, R. (2023). Brain tumor classification using deep CNN-based transfer learning approach. International Journal of Biology and Biomedical Engineering, 17, 1-7.
    [CrossRef] [Google Scholar]
  23. Bhuvaji, S., Kadam, A., Bhumkar, P., Dedge, S., & Kanchan, S. (2020). Brain tumor classification (MRI) [Data set]. Kaggle. Retrieved from
    [CrossRef] [Google Scholar]
  24. Shorten, C., & Khoshgoftaar, T. M. (2019). A survey on image data augmentation for deep learning. Journal of Big Data, 6(1), 60.
    [CrossRef] [Google Scholar]
  25. Zhuang, F., Qi, Z., Duan, K., Xi, D., Zhu, Y., Zhu, H., ... & He, Q. (2020). A comprehensive survey on transfer learning. Proceedings of the IEEE, 109(1), 43-76.
    [CrossRef] [Google Scholar]
  26. Simonyan, K., & Zisserman, A. (2014). Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556.
    [CrossRef] [Google Scholar]
  27. He, K., Zhang, X., Ren, S., & Sun, J. (2016). Deep residual learning for image recognition. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR) (pp. 770-778). IEEE.
    [CrossRef] [Google Scholar]
  28. Chollet, F. (2017, July). Xception: Deep learning with depthwise separable convolutions. In 2017 IEEE conference on computer vision and pattern recognition (CVPR) (pp. 1800-1807). IEEE.
    [CrossRef] [Google Scholar]
  29. Howard, A. G., Zhu, M., Chen, B., Kalenichenko, D., Wang, W., Weyand, T., Andreetto, M., & Adam, H. (2017). MobileNets: Efficient convolutional neural networks for mobile vision applications. arXiv preprint arXiv:1704.04861.
    [CrossRef] [Google Scholar]
  30. Chicho, B. T., & Sallow, A. B. (2021). A comprehensive survey of deep learning models based on Keras framework. Journal of Soft Computing and Data Mining, 2(2), 49-62.
    [CrossRef] [Google Scholar]
  31. Tajbakhsh, N., Shin, J. Y., Gurudu, S. R., Hurst, R. T., Kendall, C. B., Gotway, M. B., & Liang, J. (2016). Convolutional neural networks for medical image analysis: Full training or fine tuning?. IEEE transactions on medical imaging, 35(5), 1299-1312.
    [CrossRef] [Google Scholar]
  32. Grandini, M., Bagli, E., & Visani, G. (2020). Metrics for multi-class classification: an overview. arXiv preprint arXiv:2008.05756.
    [CrossRef] [Google Scholar]
  33. Tharwat, A. (2021). Classification assessment methods. Applied Computing and Informatics, 17(1), 168-192.
    [CrossRef] [Google Scholar]
  34. Ying, X. (2019). An overview of overfitting and its solutions. Journal of Physics: Conference Series, 1168(2), 022022.
    [CrossRef] [Google Scholar]
  35. Kingma, D. P., & Ba, J. (2014). Adam: A method for stochastic optimization. arXiv preprint arXiv:1412.6980.
    [CrossRef] [Google Scholar]

Cite This Article

APA Style
Agarwal, S. K., & Gupta, Y. K. (2026). A Comparative Analysis of Various Transfer Learning-Based Deep Learning Frameworks Using Brain Tumor MRI. ICCK Transactions on Machine Intelligence, 2(4), 200-212. https://doi.org/10.62762/TMI.2025.919091
Export Citation
RIS Format
Compatible with EndNote, Zotero, Mendeley, and other reference managers
TY  - JOUR
AU  - Agarwal, Sunil Kumar
AU  - Gupta, Yogesh Kumar
PY  - 2026
DA  - 2026/10/19
TI  - A Comparative Analysis of Various Transfer Learning-Based Deep Learning Frameworks Using Brain Tumor MRI
JO  - ICCK Transactions on Machine Intelligence
T2  - ICCK Transactions on Machine Intelligence
JF  - ICCK Transactions on Machine Intelligence
VL  - 2
IS  - 4
SP  - 200
EP  - 212
DO  - 10.62762/TMI.2025.919091
UR  - https://www.icck.org/article/abs/TMI.2025.919091
KW  - Brain tumor MRI classification
KW  - transfer learning
KW  - pre-trained model
KW  - VGG16
KW  - Xception
KW  - ResNet50
KW  - MobileNetV1
AB  - Brain tumors are a critical and challenging health issue worldwide, and they often reduce patient survival if they are not identified at an early stage. This study presents an automatic approach to identify and classify brain tumor magnetic resonance imaging (MRI) scans using several pre-trained deep learning frameworks and compares their relative performance. Four popular frameworks, namely VGG16, Xception, ResNet50, and MobileNetV1, were fine-tuned with a transfer learning technique on 2870 brain tumor MRI training images to predict four classes (glioma, meningioma, pituitary tumor, and no tumor). A quantitative comparison among all applied frameworks was performed using accuracy, precision, recall, and F1-score. On the held-out test set, VGG16 achieved the highest accuracy (70.1%), followed by Xception (63.7%), MobileNetV1 (53.3%), and ResNet50 (50.8%). The results indicate that VGG16 and Xception outperform the other two frameworks under the same transfer learning setting, while all models show low recall for the glioma class. The study provides a baseline comparison of pre-trained frameworks for brain tumor MRI classification and outlines directions for future research.
SN  - 3068-7403
PB  - Institute of Central Computation and Knowledge
LA  - English
ER  - 
BibTeX Format
Compatible with LaTeX, BibTeX, and other reference managers
@article{Agarwal2026A,
  author = {Sunil Kumar Agarwal and Yogesh Kumar Gupta},
  title = {A Comparative Analysis of Various Transfer Learning-Based Deep Learning Frameworks Using Brain Tumor MRI},
  journal = {ICCK Transactions on Machine Intelligence},
  year = {2026},
  volume = {2},
  number = {4},
  pages = {200-212},
  doi = {10.62762/TMI.2025.919091},
  url = {https://www.icck.org/article/abs/TMI.2025.919091},
  abstract = {Brain tumors are a critical and challenging health issue worldwide, and they often reduce patient survival if they are not identified at an early stage. This study presents an automatic approach to identify and classify brain tumor magnetic resonance imaging (MRI) scans using several pre-trained deep learning frameworks and compares their relative performance. Four popular frameworks, namely VGG16, Xception, ResNet50, and MobileNetV1, were fine-tuned with a transfer learning technique on 2870 brain tumor MRI training images to predict four classes (glioma, meningioma, pituitary tumor, and no tumor). A quantitative comparison among all applied frameworks was performed using accuracy, precision, recall, and F1-score. On the held-out test set, VGG16 achieved the highest accuracy (70.1\%), followed by Xception (63.7\%), MobileNetV1 (53.3\%), and ResNet50 (50.8\%). The results indicate that VGG16 and Xception outperform the other two frameworks under the same transfer learning setting, while all models show low recall for the glioma class. The study provides a baseline comparison of pre-trained frameworks for brain tumor MRI classification and outlines directions for future research.},
  keywords = {Brain tumor MRI classification, transfer learning, pre-trained model, VGG16, Xception, ResNet50, MobileNetV1},
  issn = {3068-7403},
  publisher = {Institute of Central Computation and Knowledge}
}

Article Metrics

Citations
Crossref
0
Scopus
0
Views
16
PDF Downloads
3

Publisher's Note

ICCK stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and Permissions

Institute of Central Computation and Knowledge (ICCK) or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ICCK Transactions on Machine Intelligence
ICCK Transactions on Machine Intelligence
ISSN: 3068-7403 (Online)
Portico
Preserved at
Portico