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Volume 1, Issue 2, Journal of Artificial Intelligence in Bioinformatics
Volume 1, Issue 2, 2025
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Journal of Artificial Intelligence in Bioinformatics, Volume 1, Issue 2, 2025: 58-68

Open Access | Research Article | 25 October 2025
RetinoNet: An Efficient MobileNetV3-Based Model for Diabetic Retinopathy Detection Using Multi-Scale Feature Fusion
1 School of Computer Science and Engineering, Central South University, Changsha 410017, China
2 School of Computer Science, Harbin Institute of Technology, Shenzhen 518055, China
3 School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China
4 Department of Mathematics and Computer Science, University of Catania, 95131 Catania, Italy
* Corresponding Author: Muhammad Usman Saeed, [email protected]
Received: 16 August 2025, Accepted: 03 September 2025, Published: 25 October 2025  
Abstract
Diabetic retinopathy (DR) is a leading cause of blindness globally, requiring timely detection and classification to prevent vision loss. Deep learning techniques offer significant potential for automating DR detection by analyzing retinal fundus images with high precision. This paper proposes a RetinoNet model that consists of MobileNetV3, Convolutional Block Attention Module (CBAM), Atrous Spatial Pyramid Pooling (ASPP), and Feature Pyramid Network (FPN). MobileNetV3 provides a lightweight and efficient foundation for feature extraction, while CBAM emphasizes critical spatial and channel information, enabling the detection of subtle retinal abnormalities. ASPP captures multi-scale contextual information through atrous convolutions, improving the model's ability to identify lesions of varying sizes and shapes. FPN combines hierarchical features from multiple network levels, ensuring both fine-grained details and high-level semantics are leveraged for accurate classification. The model was trained on the APTOS dataset. Evaluation metrics such as accuracy, precision, recall, and F1 score demonstrate the effectiveness of the proposed model in achieving state-of-the-art performance for DR detection and classification across five severity levels. This approach addresses computational challenges and improves generalization, making it suitable for both clinical and remote healthcare applications.

Graphical Abstract
RetinoNet: An Efficient MobileNetV3-Based Model for Diabetic Retinopathy Detection Using Multi-Scale Feature Fusion

Keywords
diabetic retinopathy
feature fusion
bio-informatics
multi-scale

Data Availability Statement
Data will be made available on request.

Funding
This work was supported without any funding.

Conflicts of Interest
The authors declare no conflicts of interest.

Ethical Approval and Consent to Participate
This study uses the anonymized, public APTOS 2019 dataset (CC BY-NC-SA 3.0 license). No human subjects, identifiable data, or interactions were involved. Ethical approval and consent are not required under guidelines for secondary data analyses (e.g., Helsinki Declaration).

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Cite This Article
APA Style
Saeed, M. U., Dastgir, A., Ghani, M. A. N. U., & Manzoor, A. (2025). RetinoNet: An Efficient MobileNetV3-Based Model for Diabetic Retinopathy Detection Using Multi-Scale Feature Fusion. Journal of Artificial Intelligence in Bioinformatics, 1(2), 58–68. https://doi.org/10.62762/JAIB.2025.322062

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